Why does the cerebral cortex have folds

It is expected that this study will pave a way to elucidate brain evolution, up to the human brain, which was previously quite difficult with mice, a widely used model animal. In addition, humans suffer, although rarely, from diseases due to gyrus impairment, the pathogenesis of which is largely unknown. The new technique we have developed in this study is expected to lead to elucidation of the etiology of various diseases including those mentioned above, which was difficult to investigate in the mouse.

The fold protrusion of the cerebral cortex surface. The gyrus is thought to have been developed in the process of evolution. The gyrus allows accommodation of a large number of neurons in the cerebral cortex, which has had much to do with development of higher brain functions.

Although the gyrus attracts much research attention, mechanisms of its formation are still largely unknown. Name of the anterior region of the brain.

The human cerebral cortex is especially well developed in comparison with that of other animals so it is thought to be important in higher brain functions. Impairment of the cerebral cortex is considered to cause various neurological diseases and psychiatric disorders. It is one of the most important regions of the brain and attracts much attention in brain research.

A higher mammal akin to the weasel. The ferret has a more developed brain than the mouse and has gyri. Hence, the ferret is used as a model animal in this study.

Few studies have been done on ferret genetics and our research group is the world leader in this field. One of techniques to selectively 'edit' a target portion of a genome, including knocking out genes. Materials provided by Kanazawa University. Note: Content may be edited for style and length. There's a good reason for this: whether a fold forms depends not only on the overall growth of the cortex, but also the physical properties of that part of the cortex.

For example, thinner regions tend to fold more easily than others, Ronan said. Though the brains' ridges and valleys — called gyri and sulci, respectively — look random, they're actually consistent across individuals, and even some species.

Ronan said this consistency is important because it indicates that the folding has meaning. Ultimately, the physical properties and unique folding patterns of each cortex region are linked to its function. But obviously, we're at the top of the evolutionary tree, and they're not. Aherne, W. Akert, K. Warren and K. Akert, eds. Alderson, A. PubMed Google Scholar. Allman, J. Anker, M.

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